AN RNA-BASED CLINICAL DIAGNOSTIC ASSAY USED TO IDENTIFY ACTIVE MICROBIAL INFECTIONS
Studies reveal the clinical efficacy of the CSI-Dx assay.

APPLIED RESEARCH

Studies reveal the efficacy of the CSI-Dx technology in a variety of clinical applications.

Because of their associated poor clinical outcomes, unusual organisms resulting in infection should not be treated equivalently to a usual pathogenic organism. Identification of unusual organisms through molecular and genetic techniques should help aid in antibiotic selection in conjunction with surgery, as indicated. Because of the associated poor clinical outcomes of unusual organisms and polymicrobial infections, the results of these newer techniques should not be ignored, but instead used to help inform therapeutic choices.

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Osteonecrosis of the femoral head is a poorly understood condition that may lead to progressive destruction of the hip joint. Its incidence is common between the third and fifth decades of life and it is the diagnosis behind 5–18% of annually performed total hip arthroplasties (THAs) in the USA. Regarding the high rate of complications of THA in that age group, authors have agreed on the importance of joint-preservation techniques for this disease but techniques vary to establish a generally accepted algorithmic approach.

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The Second International Consensus Meeting (ICM) on Musculoskeletal Infection was held in July 2018 in Philadelphia, Pennsylvania. This meeting involved contributions from an international multidisciplinary consortium of experts from orthopaedic surgery, infectious disease, pharmacology, rheumatology, microbiology, and others. Through strict delegate engagement in a comprehensive 13-step consensus process based on the Delphi technique, evidence-based consensus guidelines on musculoskeletal infection were developed.

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Crohn’s disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures of CD in stool samples from six twin pairs that were either healthy, or that had CD in the ileum (ICD) or colon (CCD). Integration of these omics approaches revealed several genes, proteins, and pathways that primarily differentiated ICD from healthy subjects, including depletion of many proteins in ICD.

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